明振华

2021年06月28日 16:36  点击:[]


明振华教授,博士,博/硕士生导师

邮箱:zhming@gxu.edu.cn

研究方向:植物病原体致病与植物免疫


个人简介:

2010年在山东大学生物技术专业获得学士学位,2015年在清华大学生物学专业获得博士学位。主要从事信号分子生物合成、感知与信号传递的结构与生化研究,方向是植物病原体致病与植物免疫。目前任广西生物化学与分子生物学会理事。


科研成果:

阐明了植物分枝激素独脚金内酯、第二信使cGMP-AMP、植物细胞分裂素、锌离子等重要信号分子的感知或生物学合成的结构机理。近年来以第一或通讯作者身份(含共同)在Nature、Cell Research、Nucleic Acids Research、Frontiers in Plant Science、Journal of Structural Biology等国际权威杂志发表SCI论文。


科研项目:

1. 国家自然科学基金青年科学基金项目,锌调蛋白Zur识别两类靶标DNA的结构基础,2018/01-2020/12,22万元,主持,已结题

2. 广西自然科学基金杰出青年科学基金项目,植物免疫信号分子合成与感知的结构机理,2021/01-2024/12,60万元,主持,在研

3. 国家自然科学基金面上项目,bE2-bW1复合体调控甘蔗黑穗病菌丝状生长的机制,2019/01-2022/12,59万元,参与,在研


代表性论文:

1. Ruifeng Yao#, Zhenhua Ming#, Liming Yan#, Suhua Li#, Fei Wang, Sui Ma, Caiting Yu, Mai Yang, Li Chen, Linhai Chen, Yuwen Li, Chun Yan, Di Miao, Zhongyuan Sun, Jianbin Yan, Yuna Sun, Lei Wang, Jinfang Chu, Shilong Fan, Wei He, Haiteng Deng, Fajun Nan, Jiayang Li, Zihe Rao*, Zhiyong Lou* and Daoxin Xie* (2016) DWARF14 is a non-canonical hormone receptor for strigolactone. Nature. 536(7617):469-73.

2. Zhenhua Ming#, Wei Wang#, Yuchen Xie, Pengfei Ding, Yuchao Chen, Dazhi Jin, Yuna Sun, Bin Xia, Liming Yan* and Zhiyong Lou* (2014) Crystal structure of the novel di-nucleotide cyclase from Vibrio cholerae (DncV) responsible for synthesizing a hybrid cyclic GMP-AMP. Cell Res. 24(10):1270-3.

3. Fenmei Liu#, Zihui Su#, Peng Chen, Xiaolin Tian, Lijie Wu, Dong-Jie Tang, Peifang Li, Haiteng Deng, Pengfei Ding, Qiang Fu, Ji-Liang Tang*, Zhenhua Ming* (2021) Structural basis for zinc-induced activation of a zinc uptake transcriptional regulator. Nucleic Acids Res. doi: 10.1093/nar/gkab432.

4. Muxue Lu#, Guangze Yang#, Peifang Li#, Zhigang Wang, Shan Fu, Xiang Zhang, Xi Chen, Mingxing Shi, Zhenhua Ming*, Jixing Xia* (2018) Bioinformatic and Functional Analysis of a Key Determinant Underlying the Substrate Selectivity of the Al Transporter, Nrat1. Front Plant Sci. 9:606.

5. Peng Chen#, Xi Jiao#, Yukun Zhang#, Lijie Wu#, Dong-jie Tang, Peifang Li, Xiaoxuan Chen, Dong Chao, Ji-Liang Tang*, Zhenhua Ming* (2019) The crystal structure of the phytopathogenic bacterial sensor PcrK reveals different cytokinin recognition mechanism from the plant sensor AHK4. J Struct Biol. 208(1):69-76.

 



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