Synthetic Biology Laboratory
PI：
Li Weihui, professor, doctoral/master's supervisor, postdoctoral cooperation supervisor, Deputy Secretary of the Party Committee and deputy dean of scientific research of the College, Guangxi Jieqing, Guangxi Bagui Youth Top talent, National Institute of Education Administration, the third period of high level talent training class. In December 2013, he graduated from Huazhong Agricultural University, majoring in Microbiology, and obtained his doctorate degree. From January 2014 to January 2019, he worked as a postdoctoral researcher at the State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University. In February 2019, he was introduced to the College of Life Science and Technology of Guangxi University as a high-level talent. Academic leader and permanent member of the State Key Laboratory for Conservation and Utilization of Subtropical Agricultural Biological Resources; And Member of Guangxi Microbiology and Enzyme Engineering Technology Research Center. He has won the National Scientific Research Outstanding Achievement Award (Second prize in Natural Science, an important member), the Outstanding sponsor of China Postdoctoral Science Foundation, the Outstanding Postdoc, the outstanding doctoral dissertation of Hubei Province and the third Outstanding Academic Paper of Wuhan Natural Science and other awards and honors. Reviewer of international journals such as Nucleic Acids Research, Synthetic and Systems Biotechnology and Microbiology Spectrum, review expert of National Natural Science Foundation of China, review expert of China Postdoctoral Science Foundation, review expert of National Research Platform, expert of Guangxi, Jiangxi and Jiangsu Science and Technology Expert Database, etc. The achievements obtained have been published in internationally renowned journals such as Nat Commun (2 articles), Nucleic Acids Res (3 articles) and PLOS Pathog, etc. The average impact factor of the representative papers is 14.69. As the project host, he undertook 3 projects of National Natural Science Foundation, 1 sub-project of National Key Research and development Plan, Guangxi Outstanding Youth Science Foundation and many other provincial and ministerial level projects.
Team members：
Lu Jie, associate professor, deputy dean of the College of Life Science and Technology, Guangxi University. Communication Review Expert of the National Natural Science Foundation of China Project, and Guangxi Enterprise Science and Technology Commissioner. The main courses taught include Modern Instrumental Analysis, Biochemistry, Drug Analysis, Natural Pharmaceutical Chemistry, Comprehensive Experiments in Biopharmaceuticals, and Biochemical Experiments. Dedicated to the research of nano electrochemical biosensors, natural product separation, and product development. He has published more than 50 high-level papers in domestic and foreign journals, obtained 3 invention patent authorizations as the first inventor, and has host and participated in multiple national and provincial level projects.
Lv Boyan，assistant Professor. In 2021, She graduated from Fujian Normal University and obtained her doctorate degree. After graduating with a PhD, She worked as a postdoctoral researcher at Fujian Normal University. Mainly focusing on research objects such as Escherichia coli and Mycobacterium tuberculosis, to study the prevention and control intervention strategies and bactericidal mechanisms of their drug resistance. Published 6 papers in internationally renowned journals, and obtained 1 invention patent authorization as the first inventor. Host and participated in 4 scientific research projects.
Tuberculosis is a zoonotic disease caused by infection with Mycobacterium tuberculosis complex, which is the most deadly single infectious disease in terms of global mortality. The reason for the strong virulence of Mycobacterium tuberculosis is mainly because it can survive long term in macrophages to achieve immune escape. Currently, more than 20 transcription factors have been reported in Mycobacterium tuberculosis, which widely regulate its resistance to oxidative stress, reductive stress, acid stress, nutritional starvation, and other adverse conditions. Of note, some transcription factors of Mycobacterium tuberculosis simultaneously regulate its resistance to first-line antibiotics such as β-lactams, macrolides, and quinolones. In recent years, with the decrease in BCG vaccine efficacy, the increase in the number of people infected with HIV, and the rising drug resistance rates of first-line anti-tuberculosis drugs such as isoniazid, the study of the pathogenic and drug resistance mechanisms of Mycobacterium tuberculosis has become urgent.
Our research group primarily focuses on elucidating the specific mechanisms by which transcription factors of Mycobacterium tuberculosis influence its physiological phenotypes and drug resistance. Additionally, we aim to determine the impact of pathogenic genes of Mycobacterium tuberculosis on its physiological state and leverage these insights to identify novel anti-tuberculosis drugs.
Research direction:
1. The discovery of bacterial second messenger receptor and its function;
2. Microbial and drug targets;
3. Microbial infection and host immunity.
Welcome outstanding graduate students and postdoctoral fellows to join our research group and contribute our efforts to the cause of human health!
