黄奔

2021年06月28日 16:31  点击:[]

 

黄奔研究员,博士博/硕士生导师

 

邮箱:arihuangben@@yahoo.com; benhuang@gxu.edu.cn

研究方向:动物繁殖与干细胞生物学

 

个人简介:

广西高校引进海外高层次人才“百人计划”入选(2013年),2001,2004和2007年在广西大学畜牧兽医和动物遗传育种与繁殖专业分别获学士,硕士和博士学位,20013年在新西兰皇家研究院农业研究所完成博士后研究。 


科研成果:

主要从事多能干细胞,体细胞重编程以及转分化的相关研究。先后分离培养或诱导获得多个物种的多能干细胞系,在国际上创新性的建立了小分子化合物诱导体细胞转分化为功能性乳腺上皮细胞以及功能性神经元的技术体系,并阐明了转分化的分子机制,为后续的临床转化和应用奠定基础。近年来以第一作者/通讯作者身份在Stem Cell Development, Biology of Reproduction, Theriogenology, Reproduction in Domestic Animals等国际权威杂志发表SCI论文20余篇。)


科研项目:

1.广西大学科研基金项目,水牛多能干细胞培养体系优化的研究,2013.10-2016.10,15万,主持,已结

2.广西自然科学基金留学回国重点项目,水牛多能干细胞培养体系优化及分化的研究,2014.06-2017.05,30万,主持,已结

3.广西高校引进高层次人才“百人计划”,2014.04-2019.03,100万(包括广西大学配套50万),主持,已结

4.国家自然科学基金项目,小分子化合物诱导山羊多能干细胞(CiPSC)的研究,2015.01-2017.12.31,24万,主持,已结

5.国家自然科学基金项目,促进水牛iPSC向初始态转化的分子机制探讨以及候选初始态分子标记筛选,2017.01-2020.12.31,42万, 主持,在研

6.广西自然科学基金重点项目, 利用无外源基因整合诱导体系获得高产地中海奶水牛iPSC及其重编程机理的研究2017.09-2021.08,40万,主持,在研

7.广西重点研发计划项目,山羊一胎多羔技术平台的优化及推广,2018.10-2021.12,40万,主持,在研

8.国家自然科学基金项目,完全小分子化合物诱导山羊耳缘成纤维细胞转分化为乳腺上皮细胞(ciMECs)的分子机制研究,2020.01-2023.12,40万,主持,在研


代表性论文:

  1. Jiao Y, Zhu S, Li J, Jam Zaheer A, Li M,Huang B.PS48 promotes in vitro maturation and developmental competence of porcine oocytes through activating PI3K/Akt signaling pathway.Reprod Domest Anim. 2020 Dec;55(12):1678-1687. doi: 10.1111/rda.13818.

  2. Jiao Y, Li J, Zhu S, Ahmed JZ, Li M, Shi D,Huang B.PI3K inhibitor reduces in vitro maturation and developmental competence of porcine oocytes.Theriogenology. 2020 Aug 14;157:432-439. doi: 10.1016/j.theriogenology.

  3. Jiao Y, Gao B, Wang G, Li H, Ahmed JZ, Zhang D, Ye S, Liu S, Li M, Shi D,Huang B.The key long non-coding RNA screening and validation between germinal vesicle and metaphase II of porcine oocyte in vitro maturation.Reprod Domest Anim.2020 Mar;55(3):351-363. doi: 10.1111/rda.13620. Epub 2020 Jan 23.

  4. Ruan Z, Zhao X, Li Z, Qin X, Shao Q, Ruan Q, Deng Y, Jiang J,Huang B*(并列通信作者), Lu F, Shi D.Effect of sex differences in donor foetal fibroblast on the early development and DNA methylation status of buffalo (Bubalus bubalis) nuclear transfer embryos.Reprod Domest Anim.2019 Jan;54(1):11-22. doi: 10.1111/rda.13286. Epub 2018 Aug 13.

  5. Li L, Zhang D, Ren Y, Ye S, Zheng B, Liu S, Ahmed JZ, Li M, Shi D,Huang B*.The modification of mitochondrial energy metabolism and histone of goat somatic cells under small molecules compounds induction.Reprod Domest Anim. 2019 Feb;54(2):138-149. doi: 10.1111/rda.13304. Epub 2019 Feb 4.

  6. Ruan Z, Zhao X, Qin X, Luo C, Liu X, Deng Y, Zhu P1, Li Z,Huang B*(并列通信作者), Shi D, Lu F. DNA methylation and expression of imprinted genes are associated with the viability of different sexual cloned buffaloes.Reprod Domest Anim. 2018 Feb;53(1):203-212

  7. Zhu X, Li L, Gao B, Zhang D, Ren Y, Zheng B, Li M, Shi D,Huang B*.Early development of porcine parthenogenetic embryos and reduced expression of primed pluripotent marker genes under the effect of lysophosphatidic acid.Reprod Domest Anim.2018 Oct;53(5):1191-1199. doi: 10.1111/rda.13226.

  8. Sun JM, Cui KQ, Li ZP, Lu XR, Xu ZF, Liu QY*,Huang B*(并列通信作者),Shi DS*.Suberoylanilide hydroxamic acid, a novel histone deacetylase inhibitor, improves the development and acetylation level of miniature porcine handmade cloning embryos.Reprod Domest Anim. 2017 Oct;52(5):763-774

  9. Nong W,Xie TS,Li LY,Lu AG,Mo J,Gou YF,Lan G,Jiang H,Len J,Li MM*,Jiang QY*,Huang B*.Qualitative Analyses of Protein Phosphorylation in Bovine Pluripotent Stem Cells Generated from Embryonic Fibroblasts.Reprod Domest Anim.2015 Dec;50(6):989-98. doi: 10.1111/rda.12619

  10. Xiaocan Lei, Kuiqing Cui, Qingyou Liu, Haihang Zhang, Zhipeng Li,Ben Huang*(并列通信作者),Deshun Shi* .Exogenousestradiolbenzoateinduces spermatogenesis disorder through influencing apoptosis and estrogen receptor signaling pathway.Reprod Domest Anim.2016 Feb;51(1):75-84. doi: 10.1111/rda.12648.

  11. Lanyu Li*,Mengmei Li*, Sufang Yan*, Jun Zhang,Zhipeng Li,Haihang Zhang,Lulu Zhu,Xiusheng Zhu,Qingyou Liu,Deshun Shi,Ben Huang*.Inhibition of FGF signaling pathway augments the expression of pluripotency and trophoblast lineage marker genes in porcine parthenogenetic blastocyst.Reprod Domest Anim. 2016 Oct; 51(5):649-56

  12. Zhu, P., Liu, Q., Liu, S., Su, X., Feng, W., Lei, X., Liu, J., Cui, K.,Huang, B*(并列通信作者)and Shi, D*. Generation of Foxo3-targeted Mice by Injection of mRNAs Encoding Transcription Activator-like Effector Nucleases (TALENs) into Zygotes.Reproduction in Domestic Animals,2015 Jun;50(3):474-83. doi: 10.1111/rda.12515

  13. V. Verma,B. Huang(并列第一, P.K.Kallingappa, B. Oback*. Dual kinase inhibition maintains pluripotency in finite bovine embryonic cell lines.Stem cells and development.2013 Jun 1; 22(11):1728-42.

    14.D. Hanna,B. Huang (并列第一), B. Oback*. Inhibition of MAP2K and GSK3 signaling promotes bovine blastocyst development and epiblast-associated expression of pluripotency factors.Biology of Reproduction.2013 Mar 28;88(3):74-83.


科研奖励:

  1. 水牛体细胞克隆和干细胞建系关键技术与机理的研究,广西自然科学奖一等奖,2015年,石德顺、陆凤花、刘庆友、杨素芳、韦英明、黄奔、邓彦飞



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