周磊

2021年06月28日 16:27  点击:[]

周磊教授,博士,博士生导师

邮箱:zhoulei@gxu.edu.cn

研究方向: 动物营养、功能基因与代谢稳态,营养代谢的组学研究,饲料添加剂开发


个人简介:

入选广西“百人计划”(2014年)、广西青年五四奖章(2016年)、广西优秀专家(2018年)、广西高层次人才(2019年)、广西青年科技奖(2021)。2007年获华中农业大学生命科学技术学院生物化学与分子生物学博士学位,2008--2009年公派法国原子能委员会开展访问研究,2014--2015年于美国宾夕法尼亚大学开展博士后研究。先后留学德国杜塞尔多夫大学、法国原子能委员会(巴黎)和美国宾夕法尼亚大学(费城)。现任广西大学动物科学技术学院教授,博士生导师,副院长。获得国家自然科学基金、广西杰出青年科学基金、霍英东青年教师基金、广西自然科学基金重点项目等,兼任国家重点研发计划评审专家、中国畜牧兽医学会动物遗传育种学分会、动物生理生化学分会理事。


科研成果:

主要从事动物营养代谢调控研究和新型饲料添加剂的开发,旨在提高饲料利用率和动物的产品质量。目前取得的研究进展:在动物整体水平上,发现抵抗素减少线粒体、增强脂肪异位沉积;在细胞水平上,证实脂肪细胞因子参与葡萄糖代谢、肌肉发育及炎症反应;在遗传水平上,开展畜禽脂肪代谢相关基因的克隆及转录调控研究。开展研究工作以来,在《Hepatology》和《Nucleic Acids Research》等国内外高水平学术刊物上发表SCI论文40余篇。


科研项目:

1. 广西杰出青年科学基金项目,肝脂肪变性的发生机制及调控,2021/01-2024/12,60万,主持,在研

2. 广西自然科学基金重点项目,CIDEC调控外源性脂肪吸收的机制研究,2020/01-2024/01,40万,主持,在研

3. 国家重点实验室自主课题,线粒体钙离子单向转运蛋白调节脂肪代谢的机制研究,2020/06-2022/06,50万,主持,在研

4. 国家重点研发计划,日粮组成与饲养体制对畜禽健康优质肉形成的调控及机制,2018/06-2020/12,1440万,参与,在研

5. 优势特色农业新技术研究创新创业青年人才培养示范,广西科技基地和人才专项,2018/12-2021/11,150万,主持,在研

6. 国家自然科学基金地区科学基金项目,lncRNA在猪肝细胞脂肪转运中的功能及作用机制研究,2017/01-2020/12,39万,主持,已结题

7. 国家自然科学基金青年科学基金项目,CIDEC在高脂和禁食条件下的表达调控及蛋白互作研究,2014/01-2016/12,22万,主持,已结题


代表性论文:

  1. Zupeng Luo,Hailong Hu,Siqi Liu, Zhiwang Zhang, Yixing Li, Lei Zhou*(2021) Comprehensive analysis of the translatome reveals the relationship between the translational and transcriptional control in high fat diet-induced liver steatosis. RNA Biology. 18, 863-874.

  2. Siqi Liu, Dan Yang, Lin Yu, Zhier Aluo, Zhiwang Zhang, Yilin Qi, Yixing Li, Ziyi Song, Gaoxiao Xu*, Lei Zhou*(2021) Effects of lycopene on skeletal muscle-fiber type and high-fat diet-induced oxidative stress. Journal of Nutritional Biochemistry. 87, 108523.

  3. Sheng Wang, Liji Xie, Zhixun Xie*, Lijun Wan, Jiaoling Huang, Xianwen Deng, Zhi qin Xie, Sisi Luo, Tingting Zeng, Yanfang Zhang, Minxiu Zhang, Lei Zhou*(2021) Dynamic Changes in the Expression of Interferon-Stimulated Genes in Joints of SPF Chickens Infected With Avian Reovirus. Frontiers in Veterinary Science. 8, 618124.

  4. Yilin Qi, Zhiwang Zhang, Siqi Liu, Zhier Aluo, Lifang Zhang, Lin Yu, Yixing Li, Ziyi Song, and Lei Zhou*(2020) Zinc Supplementation Alleviates Lipid and Glucose Metabolic Disorders Induced by a High-Fat Diet. J Agric Food Chem.68: 5189-5200.

  5. Yixing Li, Kejing Wu, Weili Quan, Lin Yu, Shuang Chen, Chao Cheng, Qijia Wu, Shuhong Zhao, Yi Zhang*, Lei Zhou*(2019) The dynamics of FTO binding and demethylation from the m6A motifs. RNA Biology. 16: 1179-1189.

  6. Zupeng Luo, Zhiwang Zhang, Lina Tai, Lifang Zhang, Zheng Sun, Lei Zhou*(2019) Comprehensive analysis of differences of N6-methyladenosine RNA methylomes between high-fat-fed and normal mouse livers. Epigenomics.11(11): 1267-1282.  

  7. Zhanyang Tang,Yi Zhou, Jun Xiao, Huan Zhong,Weiwei Miao, Zhongbao Guo, Xu Zhang, Lei Zhou*(2019) Yongju Luo*. Transcriptome Analysis of Ovary Development in Nile Tilapia Under Different Photoperiod Regimes. Frontiers in Genetics. 10: 894.

  8. Lifang Zhang, Yilin Qi, Zhier ALuo, Siqi Liu, Zhiwang Zhang and Lei Zhou*(2019) Betaine increases mitochondrial content and improves hepatic lipid metabolism. Food Funct., 10: 216-223.

  9. Qiang Li, Yixing Li, Zhiwang Zhang, Huifang Kang, Lifang Zhang, Yuxiang Zhang, Lei Zhou*(2019) SEIPIN overexpression in the liver may alleviate hepatic steatosis by influencing the intracellular calcium level. Mol Cell Endocrinol., 488: 70-78.

  10. Li Y, Luo Z, Wu X, Zhu J, Yu K, Jin Y, Zhang Z, Zhao S, Zhou L*(2018) Proteomic Analyses of Cysteine Redox in High-Fat-Fed and Fasted Mouse Livers: Implications for Liver Metabolic Homeostasis. J Proteome Res. 17(1): 129-140.

  11. Kang Huifang, Zhang Zhiwang, Yu Lin, Li Yixing*, Liang Mingzhen, Zhou Lei*(2018) FTO reduces mitochondria and promotes hepatic fat accumulationthrough RNA demethylation. Journal of Cellular Biochemistry. 119(7): 5676-5685.

  12. Yixing Li, Huifang Kang, Yi Chu, Yi Jin, Lifang Zhang, Ranran Yang, Zhiwang Zhang, Shuhong Zhao, Lei Zhou*(2018) Cidec differentially regulates lipid deposition and secretion through two tissue-specific isoforms. Gene. 641C: 265-271.

  13. Lin Yu, Lina Tai, Lifang Zhang, Yi Chu, Yixing Li*, Lei Zhou*(2017) Comparative analyses of long non-coding RNA in lean and obese pig. Oncotarget.8(25): 41440-41450

  14. Yuxiang Zhang#, Yixing Li#, Lin Yu, Lei Zhou*(2017)Association between serum resistin concentration and hypertension: A systematic review and meta-analysis. Oncotarget. 8(25): 41529-41537.

  15. Yixing Li#, Yi Chu#, Lin Yu#, Huifang Kang, Lei Zhou*(2017) Transcriptomic analysis of Bama pig's liver in various nutritional status reveals a metabolic difference of fatty acid. Food & Function. 8: 3480-3490.

  16. Qiang Li, Yuxi Cai, Jing Huang, Xiaolan Yu, Jun Sun, Zaiqing Yang*, Zhou L*(2016)  Resistin impairs glucose permeability in EA.hy926 cells by downregulating GLUT1 expression. Mol Cell Endocrinol. 434: 127-34.

  17. Jiang Y, Lu L, Hu Y, Li Q, An C, Yu X, Shu L, Chen A, Niu C, Zhou L*(2016) Yang Z*. Resistin Induces Hypertension and Insulin Resistance in Mice via a TLR4-Dependent Pathway. Sci Rep. 6: 22193.

  18. Y Li, L Zhou*(2015) Vitamin D Deficiency, Obesity and Diabetes. Cell Mol Biol.  61(3): 35-38.

  19. Li H, Chen A, Shu L, Yu X, Gan L, Zhou L*(2014) Yang Z*. Translocation of CIDEC in hepatocytes depends on fatty acids. Genes Cells. 19(11): 793-802.

  20. Lei Zhou*(2013), Xiaolan Yu, Qingjie Meng, Hongqiang Li, Congcong Niu, Yun Jiang, Yuxi Cai, Minghui Li, Qiang Li, Chaoqiang An, Le Shu, Ao Chen, Handong Su, Yin Tang, Shen Yin, Silja Raschke, Kristin Eckardt, Juergen Eckel, Zaiqing Yang*. Resistin reduces mitochondria and induces hepatic steatosis in mice by the protein kinase C/protein kinase G/p65/PPAR gamma coactivator 1 alpha pathway. Hepatology. 57: 1384-1393.

  21. Lei Zhou(2013), Gwenaelle Le Roux, Cecile Ducrot, Stephane Chedin, Jean Labarre, Michel Riva, Christophe Carles*. Repression of class I transcription by cadmium is mediated by the Protein Phosphatase 2A. Nucleic Acids Res. 41: 6087–6097.

  22. Lei Zhou(2012) Lijie Zhang, Qingjie Meng, Congcong Niu, Dan Jin, An Yu, Li gan, Zaiqing Yang. C/EBPa promotes transcription of the porcine perilipin5 gene. Mol Cell Endocrinnol. 364:28-35.

  23. Lei Zhou(2011), Qingjie Meng, Tao Qian, Zaiqing Yang. Ginkgo biloba extract enhances glucose tolerance in hyperinsulinism-induced hepatic cells. J Nat Med. 65(1): 50-6.

  24. Lei Zhou(2007),Henrike Sell, Kristin Eckardt, Zaiqing Yang, Jürgen Eckel. Conditioned medium obtained from in vitro differentiated adipocytes and resistin induce insulin resistance in human hepatocytes. Febs Letters. 581: 4303-4308.

  25. Lei Zhou(2007), Yixing Li, Tao Nie, Shengqiu Feng, Huaping Chen, Zaiqing Yang. Clenbuterol inhibits SREBP-1c expression by activating CREB1. J Biochem Mol Biol.40(4): 525-31.

  26. Lei Zhou(2006), Yixing Li, Tao Xia, Shengqiu Feng, Xiaodong Chen, Zaiqing Yang. Resistin Overexpression Impaired Glucose Tolerance in Hepatocytes. Eur Cytokine Netw.  17(3): 189-95.

  27. Lei Zhou(2006), Tao Xia, Yixing Li, Xiaodong Chen, Yin Peng, Zaiqing Yang. Transcriptional Regulation of the Resistin Gene. Domest Anim Endocrinol. 30(2): 98-107.


科研奖励:

1. 广西青年科技奖,2021年,周磊

 

 



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