李建明

2021年10月28日 16:26  点击:[]

李建明教授 博士 博士生导师

个人简介:

李建明,1984年毕业于南京大学生物系,1990年获美国内布拉斯加林肯大学硕士学位,1995年获美国弗杰尼亚大学博士学位,1995年至1998年在美国SALK生物研究所从事博士后研究。先后任美国密歇根大学助理教授、副教授和终身正教授。现任华南农业大学林学与风景园林学院植物激素生物学研究团队负责人,二级教授,博士研究生导师。

学术贡献:

长期从事植物分子遗传学研究,在植物激素-油菜素甾醇(brassinosteroid, BR)的合成与信号转导领域做出了许多国际开创性贡献。其中拟南芥DET2的克隆及酶活性的确定为BR认定为第六类植物激素提供了关键性遗传证据;BR受体BRI1的发现开启了植物激素研究的新方向;BIN2BAK1的发现为阐明磷酸化介导的植物激素信号传导机制提供了坚实的理论依据,同时BAK1-BRI1蛋白互作的研究为后来发现调控植物生长发育及植物抗病免疫中多个受体蛋白的激活机制奠定了重要理论基础。研究成果相继发表在Science (3)Cell (3)PNAS (10)Plant Cell (8)Molecular CellNature Communications等顶尖期刊,共计70余篇高水平研究论文。一些重要发现已被写进国际上广泛使用的植物科学教科书中。近年来,带领研究团队利用BR受体突变体为遗传材料,开展了植物内质网蛋白质质量监控和相关降解机制研究,取得了许多国际领先的原创性研究成果,为深入理解植物生长发育、逆境胁迫和植物抗病机理奠定坚实的理论基础。学术兼职包括担任多个著名学术期刊如Plant Cell Physiol.JIPBMol Plant的编委,以及ScienceCellPNASPlant Cell等学术期刊审稿人和多个国内外科学基金机构的评审专家。

科研项目:

1) 国家自然科学基金重点项目,31730019,植物内质网介导的蛋白质降解机制,2018/01-2022/12278万,在研,主持

2) 国家自然科学基金面上项目,3187010520,拟南芥泛素连接酶ROBIN1BR信号通路中的功能与机制研究,2019/01-2022/1260万,在研,主持

代表性学术论文:

Mao, J., Li, W., Liu, J., and Li, J*. (2021). Versatile Physiological Functions of Plant GSK3-Like Kinases. Genes (Basel) 12.

Zhang, J., Wu, J., Liu, L., and Li, J*. (2021). The Crucial Role of Demannosylating Asparagine-Linked Glycans in ERADicating Misfolded Glycoproteins in the Endoplasmic Reticulum. Front Plant Sci 11, 625033.

Liu, X., Yang, H., Wang, Y., Zhu, Z., Zhang, W., and Li, J*. (2020). Comparative Transcriptomic Analysis to Identify Brassinosteroid Response Genes. Plant Physiol 184, 1072-1082.

Mao, J., and Li, J*. (2020). Regulation of Three Key Kinases of Brassinosteroid Signaling Pathway. Int J Mol Sci 21.

Lin, L., Zhang, C., Chen, Y., Wang, Y., Wang, D., Liu, X., Wang, M., Mao, J., Zhang, J., Xing, W., Liu, L.*, and Li, J*. (2019). PAWH1 and PAWH2 are plant-specific components of an Arabidopsis endoplasmic reticulum-associated degradation complex. Nat Commun 10, 3492.

Liu, L., and Li, J*. (2019). Communications Between the Endoplasmic Reticulum and Other Organelles During Abiotic Stress Response in Plants. Front Plant Sci 10, 749.

Liu, C., Niu, G., Zhang, H., Sun, Y., Sun, S., Yu, F., Lu, S., Yang, Y., Li, J*, and Hong, Z*. (2018). Trimming of N-Glycans by the Golgi-Localized alpha-1,2-Mannosidases, MNS1 and MNS2, Is Crucial for Maintaining RSW2 Protein Abundance during Salt Stress in Arabidopsis. Mol Plant 11, 678-690.

Zhang, X., Zhou, L., Qin, Y., Chen, Y., Liu, X., Wang, M., Mao, J., Zhang, J., He, Z., Liu, L.*, and Li, J*. (2018). A Temperature-Sensitive Misfolded bri1-301 Receptor Requires Its Kinase Activity to Promote Growth. Plant Physiol 178, 1704-1719.

Liu, Y., Zhang, C., Wang, D., Su, W., Liu, L., Wang, M., and Li, J*. (2015). EBS7 is a plant-specific component of a highly conserved endoplasmic reticulum-associated degradation system in Arabidopsis. Proc Natl Acad Sci U S A 112, 12205-12210.

Liu, Y., and Li, J*. (2014). Endoplasmic reticulum-mediated protein quality control in Arabidopsis. Front Plant Sci 5, 162.

Liu, Y., and Li, J*. (2013). An in vivo investigation of amino acid residues critical for the lectin function of Arabidopsis calreticulin 3. Mol Plant 6, 985-987.

Liu, Y., and Li, J*. (2013). A conserved basic residue cluster is essential for the protein quality control function of the Arabidopsis calreticulin 3. Plant Signal Behav 8, e23864.

Hong, Z., Kajiura, H., Su, W., Jin, H., Kimura, A., Fujiyama, K., and Li, J*. (2012). Evolutionarily conserved glycan signal to degrade aberrant brassinosteroid receptors in Arabidopsis. Proc Natl Acad Sci U S A 109, 11437-11442.

Su, W., Liu, Y., Xia, Y., Hong, Z., and Li, J*. (2012). The Arabidopsis homolog of the mammalian OS-9 protein plays a key role in the endoplasmic reticulum-associated degradation of misfolded receptor-like kinases. Mol Plant 5, 929-940.

Li, J*. (2011). Direct involvement of leucine-rich repeats in assembling ligand-triggered receptor-coreceptor complexes. Proc Natl Acad Sci U S A 108, 8073-8074.

Su, W., Liu, Y., Xia, Y., Hong, Z., and Li, J*. (2011). Conserved endoplasmic reticulum-associated degradation system to eliminate mutated receptor-like kinases in Arabidopsis. Proc Natl Acad Sci U S A 108, 870-875.

Li, J*. (2010). Regulation of the nuclear activities of brassinosteroid signaling. Curr Opin Plant Biol 13, 540-547.

Kang, B., Wang, H., Nam, K.H., Li, J., and Li, J*. (2010). Activation-tagged suppressors of a weak brassinosteroid receptor mutant. Mol Plant 3, 260-268.

Peng, P., Zhao, J., Zhu, Y., Asami, T., and Li, J*. (2010). A direct docking mechanism for a plant GSK3-like kinase to phosphorylate its substrates. J Biol Chem 285, 24646-24653.

Yan, Z., Zhao, J., Peng, P., Chihara, R.K., and Li, J*. (2009). BIN2 functions redundantly with other Arabidopsis GSK3-like kinases to regulate brassinosteroid signaling. Plant Physiol 150, 710-721.

Hong, Z., Jin, H., Fitchette, A.C., Xia, Y., Monk, A.M., Faye, L., and Li, J*. (2009). Mutations of an alpha1,6 mannosyltransferase inhibit endoplasmic reticulum-associated degradation of defective brassinosteroid receptors in Arabidopsis. Plant Cell 21, 3792-3802.

Wang, H., Zhu, Y., Fujioka, S., Asami, T., Li, J., and Li, J*. (2009). Regulation of Arabidopsis brassinosteroid signaling by atypical basic helix-loop-helix proteins. Plant Cell 21, 3781-3791.

Jin, H., Hong, Z., Su, W., and Li, J*. (2009). A plant-specific calreticulin is a key retention factor for a defective brassinosteroid receptor in the endoplasmic reticulum. Proc Natl Acad Sci U S A 106, 13612-13617.

Peng, P., Yan, Z., Zhu, Y., and Li, J*. (2008). Regulation of the Arabidopsis GSK3-like kinase BRASSINOSTEROID-INSENSITIVE 2 through proteasome-mediated protein degradation. Mol Plant 1, 338-346.

Hong, Z., Jin, H., Tzfira, T., and Li, J*. (2008). Multiple mechanism-mediated retention of a defective brassinosteroid receptor in the endoplasmic reticulum of Arabidopsis. Plant Cell 20, 3418-3429.

Jin, H., Yan, Z., Nam, K.H., and Li, J*. (2007). Allele-specific suppression of a defective brassinosteroid receptor reveals a physiological role of UGGT in ER quality control. Mol Cell 26, 821-830.

Li, J.*, and Jin, H. (2007). Regulation of brassinosteroid signaling. Trends Plant Sci 12, 37-41.

Li, J*. (2005). Brassinosteroid signaling: from receptor kinases to transcription factors. Curr Opin Plant Biol 8, 526-531.

Nam, K.H., and Li, J*. (2004). The Arabidopsis transthyretin-like protein is a potential substrate of BRASSINOSTEROID-INSENSITIVE 1. Plant Cell 16, 2406-2417.

Li, J*. (2003). Brassinosteroids signal through two receptor-like kinases. Curr Opin Plant Biol 6, 494-499.

Peng, P., and Li, J*. (2003). Brassinosteroid Signal Transduction: A Mix of Conservation and Novelty. J Plant Growth Regul 22, 298-312.

Zhao, J., Peng, P., Schmitz, R.J., Decker, A.D., Tax, F.E., and Li, J*. (2002). Two putative BIN2 substrates are nuclear components of brassinosteroid signaling. Plant Physiol 130, 1221-1229.

Nam, K.H., and Li, J*. (2002). BRI1/BAK1, a receptor kinase pair mediating brassinosteroid signaling. Cell 110, 203-212.

Li, J*., and Nam, K.H. (2002). Regulation of brassinosteroid signaling by a GSK3/SHAGGY-like kinase. Science 295, 1299-1301.

Li, J., Nam, K.H., Vafeados, D., and Chory, J. (2001). BIN2, a new brassinosteroid-insensitive locus in Arabidopsis. Plant Physiol 127, 14-22.

Li, J., and Chory, J. (1997). A putative leucine-rich repeat receptor kinase involved in brassinosteroid signal transduction. Cell 90, 929-938.

Li, J., Biswas, M.G., Chao, A., Russell, D.W., and Chory, J. (1997). Conservation of function between mammalian and plant steroid 5α-reductases. Proc Natl Acad Sci U S AS 94, 3554-3559.

Li, J., and Timko, M.P. (1996). The pc-1 phenotype of Chlamydomonas reinhardtii results from a deletion mutation in the nuclear gene for NADPH:protochlorophyllide oxidoreductase. Plant Mol Biol 30, 15-37.

Li, J., Nagpal, P., Vitart, V., McMorris, T.C., and Chory, J. (1996). A role for brassinosteroids in light-dependent development of Arabidopsis. Science 272, 398-401.

Li, J., Goldschmidt-Clermont, M., and Timko, M.P. (1993). Chloroplast-encoded chlB is required for light-independent protochlorophyllide reductase activity in Chlamydomonas reinhardtii. Plant Cell 5, 1817-1829.






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