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The power of context: how networks resolve fundamental analytical issues in proteomics
2017-03-23 17:39   审核人:

报告人:Dr. Wilson Wen Bin Goh(天津大学)
报告时间:3月24日(周五)上午11:00-12:00
报告地点:国重室北107会议室
欢迎广大师生参加! 

PERSONAL PARTICULARS
Nationality: Singaporean  

EDUCATION
2009-2013 PhD Bioinformatics and Theoretical Systems Biology, Imperial College
London
2007-2008 MSc (High Distinction) Bioinformatics and Theoretical Systems Biology,
Imperial College London
2001-2005 BSc (Honors 2:1) Life Sciences, University Scholars Program, National
University of Singapore
EMPLOYMENT HISTORY
2016-Current Associate Professor, Department of Bioengineering, Tianjin University
2014-Current Associate Professor, School of Pharmaceutical Science and Technology, Tianjin University  

2013 Visiting Fellow, Brigham and Women’s Hospital, Harvard Medical School,
Harvard University
2010-2013 Lecturer (Part-time), Republic Polytechnic Singapore  

AWARDS/HONORS
2016 Best Paper Award 15th APBioNet-INCOB Conference
2014 Peiyang Scholar, Tianjin University
2013 Association of British-Turkish Academics Doctoral Awards Competition
Honourable Mention Award
2011 10th APBioNet–1st ISCB-Asia Joint Conference Best Poster Award
2008-2013 Wellcome Trust PhD Scholarship – 1 of 5 awards; highly competitive graduate
award
2008-2013 Imperial College Overseas Research Scholarship – 1 of 2 awards; highly
competitive scholarship covering overseas fee difference for non-UK nationals
2004-2005 Agency for Science Technology and Research Pre-Graduate Scholarship –
Offered to outstanding undergraduates with minimum GPA of 4.25/5 and show exceptional promise in research and development  

JOURNAL PUBLICATIONS (REFEREED)
FEATURE SELECTION AND FUNCTIONAL/NETWORK MODELING
1. Goh WWB*, Wong LS. Spectra-first feature analysis in clinical proteomics --- A case study in
renal cancer. Journal of Bioinformatics and Computational Biology, Accepted
2. Goh WWB*. FUZZY-FISHNET: A highly reproducible protein complex-based approach for
feature selection in comparative proteomics. BMC Medical Genomics, Accepted
3. Goh WWB*, Wong LS. Evaluating feature-selection stability in next-generation proteomics.
Journal of Bioinformatics and Computational Biology, Accepted
4. Goh WWB*, Wong LS. Advancing clinical proteomics via networks: A tale of five paradigms.
Journal of Proteome Research, Accepted
5. Iwata H, Ricchiuto P, YoshidaH, Goettsch C, Hara T, Goh WWB, Yamada I, Inoue N, Mojcher
A, Fukuda D, Boothby M, Barabási A, Aikawa E, Sharma A, Singh S, Aikawa M. PARP9 and
PARP14 regulate macrophage activation. Nature Communications, Accepted
6. Singh SA, Andraski AB, Pieper B, Goh WWB, Mendivil CO, Sacks FM, Aikawa M. Multiple
apolipoprotein kinetics measured in human HDL by high resolution/accurate mass parallel
reaction monitoring. Journal of Lipid Research, 57(4):714-28, Feb 2016
7. Hutcheson JD, Goettsch C, Bertazzo S, Maldonado N, Ruiz JL, Goh WWB, Yabusaki K, Faits T,
Bouten C, Franck G, Quillard T, Libby P, Aikawa M, Weinbaum S, Aikawa E. Genesis and
growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques. Nature
Materials, 15(3):335-43, Jan 2016
8. Goh WWB*, Guo T, Aebersold R, Wong LS. Quantitative proteomics signature profiling based
on network contextualization. Biology Direct, 10:71, December 2015
9. Ricchiuto P, Sng J, Goh WWB*. Analyzing extremely small sized ratio datasets. International
Journal of Bioinformatics Research and Applications, 11(3):268-80 June 2015.
10. Goh WWB, Fan MY, Low HS, Sergot M, Wong LS. Enhancing the utility of Proteomics
Signature Profiling (PSP) with Pathway Derived Subnets (PDSs), performance analysis and
specialised ontologies. BMC Genomics, 14(35), February 2013
11. Goh WWB, Lee YH, Ramdzan Z, Chung MCM, Wong LS, Sergot MJ. A network-based
maximum link approach towards MS identifies potentially important roles for undetected
ARRB1/2 and ACTB in liver cancer progression. International Journal of Bioinformatics
Research and Applications, 8(3/4):155-170, August 2012  

12. Goh WWB, Lee YH, Ramdzan Z, Sergot M, Chung M, Wong LS. Proteomics Signature Profiling
(PSP) – A novel contextualization approach applied towards proteomics analysis. Journal of
Proteome Research, 11(3):1571-1581, March 2012
13. Goh WWB, Oikawa H, Sng J, Sergot M, Wong LS. The role of miRNAs in regulating complex
formation. Bioinformatics, 28(4):453-456, February 2012
14. Goh WWB, Lee YH, Ramdzan Z, Jin JJ, Dong DF, Lin QS, Chung M, Wong LS. A network-based
pipeline for analyzing MS data – An application towards liver cancer. Journal of Proteome
Research, 10(5):2261-2272, May 2011
NORMALIZATION TECHNIQUES, BATCH EFFECTS AND PURE STATISTICS
15. Wang W, Sue ACH, Goh WWB*. Null-hypothesis statistical testing in clinical proteomics:
With great power comes great reproducibility. Drug Discovery Today, Accepted
16. Wang W, Goh WWB*. Sample-to-sample p-value variability and its implications in
multivariate analysis. International Journal of Bioinformatics Research and Applications,
Accepted
17. Goh WWB*, Wong LS. Protein complex-based analysis is resistant to the obfuscating
consequences of batch effects --- A case study in clinical proteomics. BMC Genomics,
Accepted


 

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